Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO(−) Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle
BACKGROUND: It is believed that the endotoxin lipopolysaccharide (LPS) is implicated in the metabolic perturbations associated with both sepsis and obesity (metabolic endotoxemia). Here we examined the role of inducible nitric oxide synthase (iNOS) in skeletal muscle insulin resistance using LPS cha...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011021/ https://www.ncbi.nlm.nih.gov/pubmed/21206533 http://dx.doi.org/10.1371/journal.pone.0015912 |