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Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO(−) Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle

BACKGROUND: It is believed that the endotoxin lipopolysaccharide (LPS) is implicated in the metabolic perturbations associated with both sepsis and obesity (metabolic endotoxemia). Here we examined the role of inducible nitric oxide synthase (iNOS) in skeletal muscle insulin resistance using LPS cha...

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Detalles Bibliográficos
Autores principales:	Pilon, Geneviève, Charbonneau, Alexandre, White, Phillip J., Dallaire, Patrice, Perreault, Mylène, Kapur, Sonia, Marette, André
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011021/ https://www.ncbi.nlm.nih.gov/pubmed/21206533 http://dx.doi.org/10.1371/journal.pone.0015912

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