p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis

The retinoblastoma protein (Rb) inhibits both cell division and apoptosis, but the mechanism by which Rb alternatively regulates these divergent outcomes remains poorly understood. Cyclin dependent kinases (Cdks) promote cell division by phosphorylating and reversibly inactivating Rb by a hierarchic...

Descripción completa

Detalles Bibliográficos
Autores principales: Delston, Rachel B., Matatall, Katie A., Sun, Young, Onken, Michael D., Harbour, J. William
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012146/
https://www.ncbi.nlm.nih.gov/pubmed/20871633
http://dx.doi.org/10.1038/onc.2010.442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012146/
https://www.ncbi.nlm.nih.gov/pubmed/20871633
http://dx.doi.org/10.1038/onc.2010.442

Ejemplares similares