Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis

BACKGROUND: Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible cartilage erosion and osteoarthritic (OA) disease. Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aime...

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Detalles Bibliográficos
Autores principales: Zhu, Fei, Wang, Pu, Lee, Norman H., Goldring, Mary B., Konstantopoulos, Konstantinos
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012157/
https://www.ncbi.nlm.nih.gov/pubmed/21209926
http://dx.doi.org/10.1371/journal.pone.0015174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012157/
https://www.ncbi.nlm.nih.gov/pubmed/21209926
http://dx.doi.org/10.1371/journal.pone.0015174

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