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Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis
BACKGROUND: Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible cartilage erosion and osteoarthritic (OA) disease. Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aime...
Autores principales: | Zhu, Fei, Wang, Pu, Lee, Norman H., Goldring, Mary B., Konstantopoulos, Konstantinos |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012157/ https://www.ncbi.nlm.nih.gov/pubmed/21209926 http://dx.doi.org/10.1371/journal.pone.0015174 |
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