Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci

OBJECTIVE: Insulin receptor (IR) translocates to the nucleus, but its recruitment to gene loci has not been demonstrated. Here, we tested the hypothesis that IR and its downstream mitogenic transducers are corecruited to two prototypic insulin-inducible genes: early growth response 1 (egr-1), involv...

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Detalles Bibliográficos
Autores principales: Nelson, Joel D., LeBoeuf, Renée C., Bomsztyk, Karol
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012164/
https://www.ncbi.nlm.nih.gov/pubmed/20929976
http://dx.doi.org/10.2337/db09-1806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012164/
https://www.ncbi.nlm.nih.gov/pubmed/20929976
http://dx.doi.org/10.2337/db09-1806

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