β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency

OBJECTIVE: The islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP). Toxic oligomers of IAPP form intracellularly in β-cells in humans with type 2 diabetes, suggesting impaired cle...

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Detalles Bibliográficos
Autores principales: Costes, Safia, Huang, Chang-jiang, Gurlo, Tatyana, Daval, Marie, Matveyenko, Aleksey V., Rizza, Robert A., Butler, Alexandra E., Butler, Peter C.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012175/
https://www.ncbi.nlm.nih.gov/pubmed/20980462
http://dx.doi.org/10.2337/db10-0522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012175/
https://www.ncbi.nlm.nih.gov/pubmed/20980462
http://dx.doi.org/10.2337/db10-0522

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