Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy

OBJECTIVE: The effectiveness of tolerizing immunotherapeutic strategies, such as anti-CD40L or dendritic cells (DCs), is greater when administered to young nonobese diabetic (NOD) mice than at peak insulitis. RelB(lo) DCs, generated in the presence of an nuclear factor-κB inhibitor, induce T-regulat...

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Detalles Bibliográficos
Autores principales: Bertin-Maghit, Sebastien, Pang, Dimeng, O'Sullivan, Brendan, Best, Shannon, Duggan, Emily, Paul, Sanjoy, Thomas, Helen, Kay, Thomas W.H., Harrison, Leonard C., Steptoe, Raymond, Thomas, Ranjeny
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012178/
https://www.ncbi.nlm.nih.gov/pubmed/20980463
http://dx.doi.org/10.2337/db10-0104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012178/
https://www.ncbi.nlm.nih.gov/pubmed/20980463
http://dx.doi.org/10.2337/db10-0104

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