Both Polymorphic Variable Number of Tandem Repeats and Autoimmune Regulator Modulate Differential Expression of Insulin in Human Thymic Epithelial Cells

OBJECTIVE: Polymorphic INS-VNTR plays an important role in regulating insulin transcript expression in the human thymus that leads to either insulin autoimmunity or tolerance. The molecular mechanisms underlying the INS-VNTR haplotype-dependent insulin expression are still unclear. In this study, we...

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Detalles Bibliográficos
Autores principales: Cai, Chuan Qi, Zhang, Tao, Breslin, Mary B., Giraud, Matthieu, Lan, Michael S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012191/
https://www.ncbi.nlm.nih.gov/pubmed/20876716
http://dx.doi.org/10.2337/db10-0255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012191/
https://www.ncbi.nlm.nih.gov/pubmed/20876716
http://dx.doi.org/10.2337/db10-0255

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