The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice

The ARF tumor suppressor regulates p53 as well as basic developmental processes independent of p53, including osteoclast activation, by controlling ribosomal biogenesis. Here we provide evidence that ARF is a master regulator of bone remodeling and osteosarcoma (OS) development in mice. Arf(-/-) mic...

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Detalles Bibliográficos
Autores principales: Rauch, Daniel A., Hurchla, Michelle A., Harding, John C., Deng, Hongju, Shea, Lauren K., Eagleton, Mark C., Niewiesk, Stefan, Lairmore, Michael D., Piwnica-Worms, David, Rosol, Thomas J., Weber, Jason D., Ratner, Lee, Weilbaecher, Katherine N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012707/
https://www.ncbi.nlm.nih.gov/pubmed/21209895
http://dx.doi.org/10.1371/journal.pone.0015755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012707/
https://www.ncbi.nlm.nih.gov/pubmed/21209895
http://dx.doi.org/10.1371/journal.pone.0015755

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