Alzheimer's Aβ Peptides with Disease-Associated N-Terminal Modifications: Influence of Isomerisation, Truncation and Mutation on Cu(2+) Coordination

BACKGROUND: The amyloid-β (Aβ) peptide is the primary component of the extracellular senile plaques characteristic of Alzheimer's disease (AD). The metals hypothesis implicates redox-active copper ions in the pathogenesis of AD and the Cu(2+) coordination of various Aβ peptides has been widely...

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Detalles Bibliográficos
Autores principales: Drew, Simon C., Masters, Colin L., Barnham, Kevin J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012727/
https://www.ncbi.nlm.nih.gov/pubmed/21209855
http://dx.doi.org/10.1371/journal.pone.0015875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012727/
https://www.ncbi.nlm.nih.gov/pubmed/21209855
http://dx.doi.org/10.1371/journal.pone.0015875

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