TLR5 Activation Induces Secretory Interleukin-1 Receptor Antagonist (sIL-1Ra) and Reduces Inflammasome-associated Tissue Damage

TLR5-mediated detection of flagellin induces NF-κB mediated transcription of host defense gene expression whereas recognition of intracellular flagellin by IPAF results in maturation/secretion of the inflammasome cytokine IL-1β. The potent effects of IL-1β are counter-regulated by secretory interleu...

Descripción completa

Detalles Bibliográficos
Autores principales: Carvalho, Frederic A., Aitken, Jesse D., Gewirtz, Andrew T., Vijay-Kumar, Matam
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012739/
https://www.ncbi.nlm.nih.gov/pubmed/20844479
http://dx.doi.org/10.1038/mi.2010.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012739/
https://www.ncbi.nlm.nih.gov/pubmed/20844479
http://dx.doi.org/10.1038/mi.2010.57

Ejemplares similares