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TLR5 Activation Induces Secretory Interleukin-1 Receptor Antagonist (sIL-1Ra) and Reduces Inflammasome-associated Tissue Damage
TLR5-mediated detection of flagellin induces NF-κB mediated transcription of host defense gene expression whereas recognition of intracellular flagellin by IPAF results in maturation/secretion of the inflammasome cytokine IL-1β. The potent effects of IL-1β are counter-regulated by secretory interleu...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012739/ https://www.ncbi.nlm.nih.gov/pubmed/20844479 http://dx.doi.org/10.1038/mi.2010.57 |