Single Chain Recombinant HLA-DQ2.5/peptide Molecules Block α2-gliadin-Specific Pathogenic CD4(+) T Cell Proliferation and Attenuate Production of Inflammatory Cytokines: A Potential Therapy for Celiac Disease

Celiac disease (CD) is a disorder of the small intestine caused by intolerance to wheat gluten and related proteins in barley and rye. CD4(+) T cells play a central role in CD, recognizing and binding complexes of HLA-DQ2.5 bearing gluten peptides that have survived digestion and that are deamidated...

Descripción completa

Detalles Bibliográficos
Autores principales: Huan, J, Meza-Romero, R, Mooney, J L, Vandenbark, A A, Offner, H, Burrows, G G
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012747/
https://www.ncbi.nlm.nih.gov/pubmed/20736999
http://dx.doi.org/10.1038/mi.2010.44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012747/
https://www.ncbi.nlm.nih.gov/pubmed/20736999
http://dx.doi.org/10.1038/mi.2010.44

Ejemplares similares