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Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1

Signal transduction by the Smad pathway elicits critical biological responses to many extracellular polypeptide factors, including TGFβ and bone morphogenetic protein. Regulation of Smad signaling imparts several cytoplasmic and nuclear mechanisms, some of which entail protein phosphorylation. Previ...

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Detalles Bibliográficos
Autores principales: Morén, Anita, Raja, Erna, Heldin, Carl-Henrik, Moustakas, Aristidis
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012991/
https://www.ncbi.nlm.nih.gov/pubmed/20974850
http://dx.doi.org/10.1074/jbc.M110.190660