Cargando…

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1

Signal transduction by the Smad pathway elicits critical biological responses to many extracellular polypeptide factors, including TGFβ and bone morphogenetic protein. Regulation of Smad signaling imparts several cytoplasmic and nuclear mechanisms, some of which entail protein phosphorylation. Previ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morén, Anita, Raja, Erna, Heldin, Carl-Henrik, Moustakas, Aristidis
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012991/ https://www.ncbi.nlm.nih.gov/pubmed/20974850 http://dx.doi.org/10.1074/jbc.M110.190660

Ejemplares similares

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on the H19 Imprinting Control Region Chromatin
por: Bergström, Rosita, et al.
Publicado: (2010)

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
por: Raja, Erna, et al.
Publicado: (2015)

Suppression of Latent Transforming Growth Factor (TGF)-β1 Restores Growth Inhibitory TGF-β Signaling through microRNAs
por: Dogar, Afzal M., et al.
Publicado: (2011)

C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest
por: Fogarty, Sarah, et al.
Publicado: (2009)

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING
por: Perrett, Rebecca M, et al.
Publicado: (2013)

The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
por: Craft, Clarissa S., et al.
Publicado: (2014)

MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G
por: Yuen, Samantha, et al.
Publicado: (2011)

MAPKKK-independent Regulation of the Hog1 Stress-activated Protein Kinase in Candida albicans
por: Cheetham, Jill, et al.
Publicado: (2011)

Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)
por: Geetha, Nishamol, et al.
Publicado: (2011)

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
por: Keshwani, Malik M., et al.
Publicado: (2011)

Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
por: Harper, Matthew T., et al.
Publicado: (2010)

Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells
por: James, Richard G., et al.
Publicado: (2013)

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module
por: Glatz, Gábor, et al.
Publicado: (2013)

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication
por: Dhawan, Sangeeta, et al.
Publicado: (2016)

Sul1 and Sul2 Sulfate Transceptors Signal to Protein Kinase A upon Exit of Sulfur Starvation
por: Kankipati, Harish Nag, et al.
Publicado: (2015)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
por: Thaker, Youg R., et al.
Publicado: (2017)

Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15
por: Hayes, Sebastian D., et al.
Publicado: (2012)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1ϵ and Frizzled5
por: Bernatík, Ondřej, et al.
Publicado: (2014)

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
por: Dickinson, Robin J., et al.
Publicado: (2011)

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
por: Bassi, Rekha, et al.
Publicado: (2017)

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity
por: Sajan, Mini P., et al.
Publicado: (2014)

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors
por: Faraz, Mahmood, et al.
Publicado: (2018)

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
por: Schindl, Rainer, et al.
Publicado: (2012)

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
por: Moore, Samantha F., et al.
Publicado: (2011)

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
por: De Nardo, Dominic, et al.
Publicado: (2018)

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation
por: Staples, Christopher J., et al.
Publicado: (2010)

Neuroepithelial Transforming Gene 1 (Net1) Binds to Caspase Activation and Recruitment Domain (CARD)- and Membrane-associated Guanylate Kinase-like Domain-containing (CARMA) Proteins and Regulates Nuclear Factor κB Activation
por: Vessichelli, Mariangela, et al.
Publicado: (2012)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
por: Turban, Sophie, et al.
Publicado: (2012)

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection
por: Gold, Matthew G., et al.
Publicado: (2013)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family: A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance
por: Hemi, Rina, et al.
Publicado: (2011)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells
por: Maturi, Varun, et al.
Publicado: (2018)

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes
por: Tan, Shi-Xiong, et al.
Publicado: (2012)

Identification and Profiling of Novel α(1A)-Adrenoceptor-CXC Chemokine Receptor 2 Heteromer
por: Mustafa, Sanam, et al.
Publicado: (2012)

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes
por: Pakharukova, Natalia, et al.
Publicado: (2021)

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_o1eq3rfubfnep7l229tgkvt9dt