Modeling Single Nucleotide Polymorphisms in the Human AKR1C1 and AKR1C2 Genes: Implications for Functional and Genotyping Analyses

Enzymes encoded by the AKR1C1 and AKR1C2 genes are responsible for the metabolism of progesterone and 5α-dihydrotestosterone (DHT), respectively. The effect of amino acid substitutions, resulting from single nucleotide polymorphisms (SNPs) in the AKR1C2 gene, on the enzyme kinetics of the AKR1C2 gen...

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Detalles Bibliográficos
Autores principales: Arthur, Jonathan W., Reichardt, Juergen K. V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013106/
https://www.ncbi.nlm.nih.gov/pubmed/21217827
http://dx.doi.org/10.1371/journal.pone.0015604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013106/
https://www.ncbi.nlm.nih.gov/pubmed/21217827
http://dx.doi.org/10.1371/journal.pone.0015604

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