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Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation

BACKGROUND: Addictive drugs have in common that they cause surges in dopamine (DA) concentration in the mesolimbic reward system and elicit synaptic plasticity in DA neurons of the ventral tegmental area (VTA). Cocaine for example drives insertion of GluA2-lacking AMPA receptors (AMPARs) at glutamat...

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Detalles Bibliográficos
Autores principales: Brown, Matthew T. C., Bellone, Camilla, Mameli, Manuel, Labouèbe, Gwenael, Bocklisch, Christina, Balland, Bénédicte, Dahan, Lionel, Luján, Rafael, Deisseroth, Karl, Lüscher, Christian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013137/
https://www.ncbi.nlm.nih.gov/pubmed/21209835
http://dx.doi.org/10.1371/journal.pone.0015870