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PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins
The polyglutamine diseases are caused in part by a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of β-sheet rich aggregates. Recent evidence suggests that the misfolding mechanism is context-dependent, and that pr...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013692/ https://www.ncbi.nlm.nih.gov/pubmed/21059684 http://dx.doi.org/10.1093/nar/gkq1100 |