Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

The substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched from the natural condensation of pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol condensation generating N-alkylcarboxamide analogues of N-acetylneuraminic acid. This...

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Detalles Bibliográficos
Autores principales: Campeotto, Ivan, Bolt, Amanda H., Harman, Thomas A., Dennis, Caitriona, Trinh, Chi H., Phillips, Simon E.V., Nelson, Adam, Pearson, Arwen R., Berry, Alan
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014015/
https://www.ncbi.nlm.nih.gov/pubmed/20826162
http://dx.doi.org/10.1016/j.jmb.2010.08.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014015/
https://www.ncbi.nlm.nih.gov/pubmed/20826162
http://dx.doi.org/10.1016/j.jmb.2010.08.008

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