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Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42...

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Autores principales: Speliotes, Elizabeth K., Willer, Cristen J., Berndt, Sonja I., Monda, Keri L., Thorleifsson, Gudmar, Jackson, Anne U., Allen, Hana Lango, Lindgren, Cecilia M., Luan, Jian’an, Mägi, Reedik, Randall, Joshua C., Vedantam, Sailaja, Winkler, Thomas W., Qi, Lu, Workalemahu, Tsegaselassie, Heid, Iris M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Weedon, Michael N., Wheeler, Eleanor, Wood, Andrew R., Ferreira, Teresa, Weyant, Robert J., Segré, Ayellet V., Estrada, Karol, Liang, Liming, Nemesh, James, Park, Ju-Hyun, Gustafsson, Stefan, Kilpeläinen, Tuomas O., Yang, Jian, Bouatia-Naji, Nabila, Esko, Tõnu, Feitosa, Mary F., Kutalik, Zoltán, Mangino, Massimo, Raychaudhuri, Soumya, Scherag, Andre, Smith, Albert Vernon, Welch, Ryan, Zhao, Jing Hua, Aben, Katja K., Absher, Devin M., Amin, Najaf, Dixon, Anna L., Fisher, Eva, Glazer, Nicole L., Goddard, Michael E., Heard-Costa, Nancy L., Hoesel, Volker, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Ketkar, Shamika, Lamina, Claudia, Li, Shengxu, Moffatt, Miriam F., Myers, Richard H., Narisu, Narisu, Perry, John R.B., Peters, Marjolein J., Preuss, Michael, Ripatti, Samuli, Rivadeneira, Fernando, Sandholt, Camilla, Scott, Laura J., Timpson, Nicholas J., Tyrer, Jonathan P., van Wingerden, Sophie, Watanabe, Richard M., White, Charles C., Wiklund, Fredrik, Barlassina, Christina, Chasman, Daniel I., Cooper, Matthew N., Jansson, John-Olov, Lawrence, Robert W., Pellikka, Niina, Prokopenko, Inga, Shi, Jianxin, Thiering, Elisabeth, Alavere, Helene, Alibrandi, Maria T. S., Almgren, Peter, Arnold, Alice M., Aspelund, Thor, Atwood, Larry D., Balkau, Beverley, Balmforth, Anthony J., Bennett, Amanda J., Ben-Shlomo, Yoav, Bergman, Richard N., Bergmann, Sven, Biebermann, Heike, Blakemore, Alexandra I.F., Boes, Tanja, Bonnycastle, Lori L., Bornstein, Stefan R., Brown, Morris J., Buchanan, Thomas A., Busonero, Fabio, Campbell, Harry, Cappuccio, Francesco P., Cavalcanti-Proença, Christine, Chen, Yii-Der Ida, Chen, Chih-Mei, Chines, Peter S., Clarke, Robert, Coin, Lachlan, Connell, John, Day, Ian N.M., den Heijer, Martin, Duan, Jubao, Ebrahim, Shah, Elliott, Paul, Elosua, Roberto, Eiriksdottir, Gudny, Erdos, Michael R., Eriksson, Johan G., Facheris, Maurizio F., Felix, Stephan B., Fischer-Posovszky, Pamela, Folsom, Aaron R., Friedrich, Nele, Freimer, Nelson B., Fu, Mao, Gaget, Stefan, Gejman, Pablo V., Geus, Eco J.C., Gieger, Christian, Gjesing, Anette P., Goel, Anuj, Goyette, Philippe, Grallert, Harald, Gräßler, Jürgen, Greenawalt, Danielle M., Groves, Christopher J., Gudnason, Vilmundur, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hall, Alistair S., Havulinna, Aki S., Hayward, Caroline, Heath, Andrew C., Hengstenberg, Christian, Hicks, Andrew A., Hinney, Anke, Hofman, Albert, Homuth, Georg, Hui, Jennie, Igl, Wilmar, Iribarren, Carlos, Isomaa, Bo, Jacobs, Kevin B., Jarick, Ivonne, Jewell, Elizabeth, John, Ulrich, Jørgensen, Torben, Jousilahti, Pekka, Jula, Antti, Kaakinen, Marika, Kajantie, Eero, Kaplan, Lee M., Kathiresan, Sekar, Kettunen, Johannes, Kinnunen, Leena, Knowles, Joshua W., Kolcic, Ivana, König, Inke R., Koskinen, Seppo, Kovacs, Peter, Kuusisto, Johanna, Kraft, Peter, Kvaløy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lanzani, Chiara, Launer, Lenore J., Lecoeur, Cecile, Lehtimäki, Terho, Lettre, Guillaume, Liu, Jianjun, Lokki, Marja-Liisa, Lorentzon, Mattias, Luben, Robert N., Ludwig, Barbara, Manunta, Paolo, Marek, Diana, Marre, Michel, Martin, Nicholas G., McArdle, Wendy L., McCarthy, Anne, McKnight, Barbara, Meitinger, Thomas, Melander, Olle, Meyre, David, Midthjell, Kristian, Montgomery, Grant W., Morken, Mario A., Morris, Andrew P., Mulic, Rosanda, Ngwa, Julius S., Nelis, Mari, Neville, Matt J., Nyholt, Dale R., O’Donnell, Christopher J., O’Rahilly, Stephen, Ong, Ken K., Oostra, Ben, Paré, Guillaume, Parker, Alex N., Perola, Markus, Pichler, Irene, Pietiläinen, Kirsi H., Platou, Carl G.P., Polasek, Ozren, Pouta, Anneli, Rafelt, Suzanne, Raitakari, Olli, Rayner, Nigel W., Ridderstråle, Martin, Rief, Winfried, Ruokonen, Aimo, Robertson, Neil R., Rzehak, Peter, Salomaa, Veikko, Sanders, Alan R., Sandhu, Manjinder S., Sanna, Serena, Saramies, Jouko, Savolainen, Markku J., Scherag, Susann, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Silander, Kaisa, Sinisalo, Juha, Siscovick, David S., Smit, Jan H., Soranzo, Nicole, Sovio, Ulla, Stephens, Jonathan, Surakka, Ida, Swift, Amy J., Tammesoo, Mari-Liis, Tardif, Jean-Claude, Teder-Laving, Maris, Teslovich, Tanya M., Thompson, John R., Thomson, Brian, Tönjes, Anke, Tuomi, Tiinamaija, van Meurs, Joyce B.J., van Ommen, Gert-Jan, Vatin, Vincent, Viikari, Jorma, Visvikis-Siest, Sophie, Vitart, Veronique, Vogel, Carla I. G., Voight, Benjamin F., Waite, Lindsay L., Wallaschofski, Henri, Walters, G. Bragi, Widen, Elisabeth, Wiegand, Susanna, Wild, Sarah H., Willemsen, Gonneke, Witte, Daniel R., Witteman, Jacqueline C., Xu, Jianfeng, Zhang, Qunyuan, Zgaga, Lina, Ziegler, Andreas, Zitting, Paavo, Beilby, John P., Farooqi, I. Sadaf, Hebebrand, Johannes, Huikuri, Heikki V., James, Alan L., Kähönen, Mika, Levinson, Douglas F., Macciardi, Fabio, Nieminen, Markku S., Ohlsson, Claes, Palmer, Lyle J., Ridker, Paul M., Stumvoll, Michael, Beckmann, Jacques S., Boeing, Heiner, Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Collins, Francis S., Cupples, L. Adrienne, Smith, George Davey, Erdmann, Jeanette, Froguel, Philippe, Grönberg, Henrik, Gyllensten, Ulf, Hall, Per, Hansen, Torben, Harris, Tamara B., Hattersley, Andrew T., Hayes, Richard B., Heinrich, Joachim, Hu, Frank B., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Kaprio, Jaakko, Karpe, Fredrik, Khaw, Kay-Tee, Kiemeney, Lambertus A., Krude, Heiko, Laakso, Markku, Lawlor, Debbie A., Metspalu, Andres, Munroe, Patricia B., Ouwehand, Willem H., Pedersen, Oluf, Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Quertermous, Thomas, Reinehr, Thomas, Rissanen, Aila, Rudan, Igor, Samani, Nilesh J., Schwarz, Peter E.H., Shuldiner, Alan R., Spector, Timothy D., Tuomilehto, Jaakko, Uda, Manuela, Uitterlinden, André, Valle, Timo T., Wabitsch, Martin, Waeber, Gérard, Wareham, Nicholas J., Watkins, Hugh, Wilson, James F., Wright, Alan F., Zillikens, M. Carola, Chatterjee, Nilanjan, McCarroll, Steven A., Purcell, Shaun, Schadt, Eric E., Visscher, Peter M., Assimes, Themistocles L., Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Groop, Leif C., Haritunians, Talin, Hunter, David J., Kaplan, Robert C., Mohlke, Karen L., O’Connell, Jeffrey R., Peltonen, Leena, Schlessinger, David, Strachan, David P., van Duijn, Cornelia M., Wichmann, H.-Erich, Frayling, Timothy M., Thorsteinsdottir, Unnur, Abecasis, Gonçalo R., Barroso, Inês, Boehnke, Michael, Stefansson, Kari, North, Kari E., McCarthy, Mark I., Hirschhorn, Joel N., Ingelsson, Erik, Loos, Ruth J.F.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648/
https://www.ncbi.nlm.nih.gov/pubmed/20935630
http://dx.doi.org/10.1038/ng.686