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Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers

BACKGROUND: Beta-catenin is a multifunctional oncogenic protein that contributes fundamentally to cell development and biology. Elevation in expression and activity of β-catenin has been implicated in many cancers and associated with poor prognosis. Beta-catenin is degraded in the cytoplasm by glyco...

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Detalles Bibliográficos
Autores principales: Saifo, Maher S, Rempinski, Donald R, Rustum, Youcef M, Azrak, Rami G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014904/
https://www.ncbi.nlm.nih.gov/pubmed/21126356
http://dx.doi.org/10.1186/1476-4598-9-310