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Effects of methimazole on the elimination of irinotecan

PURPOSE: To study the possible pharmacokinetic and pharmacodynamic interactions between irinotecan and methimazole. METHODS: A patient treated for colorectal cancer with single agent irinotecan received methimazole co-medication for Graves’ disease. Irinotecan pharmacokinetics and side effects were...

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Detalles Bibliográficos
Autores principales: van der Bol, Jessica M., Visser, Theo J., Loos, Walter J., de Jong, Floris A., Wiemer, Erik A. C., van Aken, Maarten O., Planting, Andre S., Schellens, Jan H., Verweij, Jaap, Mathijssen, Ron H. J.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016232/
https://www.ncbi.nlm.nih.gov/pubmed/20680278
http://dx.doi.org/10.1007/s00280-010-1414-x