Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

BACKGROUND: The human IGF2-P4 and H19 promoters are highly active in a variety of human cancers (including bladder cancer), while existing at a nearly undetectable level in the surrounding normal tissue. Single promoter vectors expressing diphtheria toxin A-fragment (DTA) under the control regulatio...

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Detalles Bibliográficos
Autores principales: Amit, Doron, Hochberg, Abraham
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016259/
https://www.ncbi.nlm.nih.gov/pubmed/21162716
http://dx.doi.org/10.1186/1479-5876-8-134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016259/
https://www.ncbi.nlm.nih.gov/pubmed/21162716
http://dx.doi.org/10.1186/1479-5876-8-134

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