The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to su...

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Detalles Bibliográficos
Autores principales: Kostenko, Sergiy, Khan, Mahmud Tareq Hassan, Sylte, Ingebrigt, Moens, Ugo
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016492/
https://www.ncbi.nlm.nih.gov/pubmed/20640477
http://dx.doi.org/10.1007/s00018-010-0452-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016492/
https://www.ncbi.nlm.nih.gov/pubmed/20640477
http://dx.doi.org/10.1007/s00018-010-0452-1

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