Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation

The docking protein Gab2 is overexpressed in several human malignancies, including breast cancer, and is associated with increased metastatic potential. Here we report that Gab2 overexpression in MCF-10A mammary epithelial cells led to delayed cell spreading, a decrease in stress fibers and mature f...

Descripción completa

Detalles Bibliográficos
Autores principales: Abreu, Maria Teresa Herrera, Hughes, William E., Mele, Katarina, Lyons, Ruth J., Rickwood, Danny, Browne, Brigid C., Bennett, Haley L., Vallotton, Pascal, Brummer, Tilman, Daly, Roger J.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016968/
https://www.ncbi.nlm.nih.gov/pubmed/21118992
http://dx.doi.org/10.1091/mbc.E10-03-0185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016968/
https://www.ncbi.nlm.nih.gov/pubmed/21118992
http://dx.doi.org/10.1091/mbc.E10-03-0185

Ejemplares similares