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Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation
The docking protein Gab2 is overexpressed in several human malignancies, including breast cancer, and is associated with increased metastatic potential. Here we report that Gab2 overexpression in MCF-10A mammary epithelial cells led to delayed cell spreading, a decrease in stress fibers and mature f...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016968/ https://www.ncbi.nlm.nih.gov/pubmed/21118992 http://dx.doi.org/10.1091/mbc.E10-03-0185 |