Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans

BACKGROUND: Our previous work indicated that novel analogs of choline have cytoprotective effects in vitro that might be useful in neurodegenerative conditions such as Alzheimer's disease (AD). Furthermore, two lead compounds (JWB1-84-1 and JAY2-22-33) from a library of more than 50 improved co...

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Detalles Bibliográficos
Autores principales: Keowkase, Roongpetch, Aboukhatwa, Marwa, Adam, Bao-Ling, Beach, J Warren, Terry, Alvin V, Buccafussco, Jerry J, Luo, Yuan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017027/
https://www.ncbi.nlm.nih.gov/pubmed/21162742
http://dx.doi.org/10.1186/1750-1326-5-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017027/
https://www.ncbi.nlm.nih.gov/pubmed/21162742
http://dx.doi.org/10.1186/1750-1326-5-59

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