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Thermodynamic Stability of Histone H3 Is a Necessary but not Sufficient Driving Force for its Evolutionary Conservation
Determining the forces that conserve amino acid positions in proteins across species is a fundamental pursuit of molecular evolution. Evolutionary conservation is driven by either a protein's function or its thermodynamic stability. Highly conserved histone proteins offer a platform to evaluate...
Autores principales: | Ramachandran, Srinivas, Vogel, Lisa, Strahl, Brian D., Dokholyan, Nikolay V. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017104/ https://www.ncbi.nlm.nih.gov/pubmed/21253558 http://dx.doi.org/10.1371/journal.pcbi.1001042 |
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