Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

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TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR–ATRIP checkpoint kinase complex. We have now determined the crystal structure of the N-terminal region of human...

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Detalles Bibliográficos
Autores principales: Rappas, Mathieu, Oliver, Antony W., Pearl, Laurence H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017600/
https://www.ncbi.nlm.nih.gov/pubmed/20724438
http://dx.doi.org/10.1093/nar/gkq743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017600/
https://www.ncbi.nlm.nih.gov/pubmed/20724438
http://dx.doi.org/10.1093/nar/gkq743

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