Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?

Mitochondrial-DNA diseases have no effective treatments. Allotopic expression—synthesis of a wild-type version of the mutated protein in the nuclear-cytosolic compartment and its importation into mitochondria—has been proposed as a gene-therapy approach. Allotopic expression has been successfully de...

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Detalles Bibliográficos
Autores principales: Perales-Clemente, Ester, Fernández-Silva, Patricio, Acín-Pérez, Rebeca, Pérez-Martos, Acisclo, Enríquez, Jose Antonio
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017613/
https://www.ncbi.nlm.nih.gov/pubmed/20823090
http://dx.doi.org/10.1093/nar/gkq769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017613/
https://www.ncbi.nlm.nih.gov/pubmed/20823090
http://dx.doi.org/10.1093/nar/gkq769

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