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Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases
Zinc finger nucleases (ZFNs) facilitate tailor-made genomic modifications in vivo through the creation of targeted double-stranded breaks. They have been employed to modify the genomes of plants and animals, and cell-based therapies utilizing ZFNs are undergoing clinical trials. However, many ZFNs d...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017618/ https://www.ncbi.nlm.nih.gov/pubmed/20843781 http://dx.doi.org/10.1093/nar/gkq787 |