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Ice-COLD-PCR enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations
Identifying low-abundance mutations within wild-type DNA is important in several fields of medicine, including cancer, prenatal diagnosis and infectious diseases. However, utilizing the clinical and diagnostic potential of rare mutations is limited by sensitivity of the molecular techniques employed...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017621/ https://www.ncbi.nlm.nih.gov/pubmed/20937629 http://dx.doi.org/10.1093/nar/gkq899 |