Cataract-causing αAG98R-crystallin mutant dissociates into monomers having chaperone activity

PURPOSE: The G98R mutation in αA-crystallin is associated with autosomal dominant cataract in humans. We have reported that mutant G98R protein has substrate-dependent chaperone activity. Further studies on this G98R mutant protein revealed that mutant protein shows reduced oligomeric stability and...

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Detalles Bibliográficos
Autores principales: Raju, Murugesan, Santhoshkumar, Puttur, Sharma, K. Krishna
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017799/
https://www.ncbi.nlm.nih.gov/pubmed/21224997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017799/
https://www.ncbi.nlm.nih.gov/pubmed/21224997

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