E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

Oligomers of 40- or 42-mer amyloid β-protein (Aβ40, Aβ42) cause cognitive decline and synaptic dysfunction in Alzheimer's disease. We proposed the importance of a turn at Glu22 and Asp23 of Aβ42 to induce its neurotoxicity through the formation of radicals. Recently, a novel deletion mutant at...

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Detalles Bibliográficos
Autores principales: Suzuki, Takayuki, Murakami, Kazuma, Izuo, Naotaka, Kume, Toshiaki, Akaike, Akinori, Nagata, Tetsu, Nishizaki, Tomoyuki, Tomiyama, Takami, Takuma, Hiroshi, Mori, Hiroshi, Irie, Kazuhiro
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017891/
https://www.ncbi.nlm.nih.gov/pubmed/21234376
http://dx.doi.org/10.4061/2011/431320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017891/
https://www.ncbi.nlm.nih.gov/pubmed/21234376
http://dx.doi.org/10.4061/2011/431320

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