HLA-DM Captures Partially Empty HLA-DR Molecules for Catalyzed Peptide Removal

The mechanisms of HLA-DM catalyzed peptide exchange remain uncertain. We found that all stages of the interaction of DM with HLA-DR were dependent on the occupancy state of the peptide binding groove. High-affinity peptides were protected from removal by DM through two mechanisms: peptide binding in...

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Detalles Bibliográficos
Autores principales: Anders, Anne-Kathrin, Call, Melissa J., Schulze, Monika-Sarah E. D., Fowler, Kevin D., Schubert, David A., Seth, Nilufer P., Sundberg, Eric J., Wucherpfennig, Kai W.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018327/
https://www.ncbi.nlm.nih.gov/pubmed/21131964
http://dx.doi.org/10.1038/ni.1967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018327/
https://www.ncbi.nlm.nih.gov/pubmed/21131964
http://dx.doi.org/10.1038/ni.1967

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