Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective cancer cell invasion depends on reducing actomyosin contractility at sites of cell-cell contact. When actomyosin is not down-regulated...

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Detalles Bibliográficos
Autores principales: Hidalgo-Carcedo, Cristina, Hooper, Steven, Chaudhry, Shahid I., Williamson, Peter, Harrington, Kevin, Leitinger, Birgit, Sahai, Erik
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018349/
https://www.ncbi.nlm.nih.gov/pubmed/21170030
http://dx.doi.org/10.1038/ncb2133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018349/
https://www.ncbi.nlm.nih.gov/pubmed/21170030
http://dx.doi.org/10.1038/ncb2133

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