Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase

Abl kinase inhibitors targeting the ATP binding pocket are currently employed as potent anti-leukemogenic agents but drug resistance has become a significant clinical limitation. Recently, a compound that binds to the myristate pocket of Abl (GNF-5) was shown to act cooperatively with nilotinib, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Iacob, Roxana E., Zhang, Jianming, Gray, Nathanael S., Engen, John R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018526/
https://www.ncbi.nlm.nih.gov/pubmed/21264348
http://dx.doi.org/10.1371/journal.pone.0015929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018526/
https://www.ncbi.nlm.nih.gov/pubmed/21264348
http://dx.doi.org/10.1371/journal.pone.0015929

Ejemplares similares