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Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase

Abl kinase inhibitors targeting the ATP binding pocket are currently employed as potent anti-leukemogenic agents but drug resistance has become a significant clinical limitation. Recently, a compound that binds to the myristate pocket of Abl (GNF-5) was shown to act cooperatively with nilotinib, an...

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Detalles Bibliográficos
Autores principales:	Iacob, Roxana E., Zhang, Jianming, Gray, Nathanael S., Engen, John R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018526/ https://www.ncbi.nlm.nih.gov/pubmed/21264348 http://dx.doi.org/10.1371/journal.pone.0015929

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