Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic...

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Detalles Bibliográficos
Autores principales: Toda, Toshihiko, Noda, Yoshihiro, Ito, Genzo, Maeda, Masahiro, Shimizu, Takahiko
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018662/
https://www.ncbi.nlm.nih.gov/pubmed/21234330
http://dx.doi.org/10.1155/2011/617974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018662/
https://www.ncbi.nlm.nih.gov/pubmed/21234330
http://dx.doi.org/10.1155/2011/617974

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