Cargando…

Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toda, Toshihiko, Noda, Yoshihiro, Ito, Genzo, Maeda, Masahiro, Shimizu, Takahiko
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018662/ https://www.ncbi.nlm.nih.gov/pubmed/21234330 http://dx.doi.org/10.1155/2011/617974

Ejemplares similares

Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease
por: Kishimoto, Yasushi, et al.
Publicado: (2017)

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease
por: Zhu, Qing, et al.
Publicado: (2020)

Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention
por: Agca, Cansu, et al.
Publicado: (2016)

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
por: Verdile, Giuseppe, et al.
Publicado: (2006)

Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation
por: Mah, Alex L., et al.
Publicado: (2000)

Helicobacter pylori filtrate impairs spatial learning and memory in rats and increases β-amyloid by enhancing expression of presenilin-2
por: Wang, Xiu-Lian, et al.
Publicado: (2014)

Venular amyloid accumulation in transgenic Fischer 344 Alzheimer’s disease rats
por: Bishay, J., et al.
Publicado: (2022)

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production
por: Rezai-Zadeh, Kavon, et al.
Publicado: (2009)

Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
por: Nizzari, Mario, et al.
Publicado: (2012)

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
por: Weggen, Sascha, et al.
Publicado: (2012)

Presenilins in Alzheimer’s disease and frontotemporal dementia
por: Shen, Jie
Publicado: (2012)

Function and dysfunction of presenilin in Alzheimer’s disease
por: Shen, Jie
Publicado: (2013)

Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease
por: Kallhoff, Verena, et al.
Publicado: (2007)

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
por: Neitzel, Julia, et al.
Publicado: (2021)

Apple Procyanidins Suppress Amyloid β-Protein Aggregation
por: Toda, Toshihiko, et al.
Publicado: (2011)

Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
por: Ledo, Jose Henrique, et al.
Publicado: (2020)

Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice
por: Chen, Bo-Wen, et al.
Publicado: (2021)

Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
por: Parent, Angèle T., et al.
Publicado: (2010)

Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin
por: Stemmer, Nina, et al.
Publicado: (2013)

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
por: Raven, Frank, et al.
Publicado: (2017)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
por: Do, Hung N., et al.
Publicado: (2023)

The presenilins
por: Tandon, Anurag, et al.
Publicado: (2002)

A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1
por: Fitzjohn, Stephen M, et al.
Publicado: (2010)

Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice
por: Xu, Xia, et al.
Publicado: (2022)

CSF Presenilin-1 complexes are increased in Alzheimer’s disease
por: García-Ayllón, María-Salud, et al.
Publicado: (2013)

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
por: Hernández-Sapiéns, Mercedes A., et al.
Publicado: (2021)

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice
por: Niikura, Takako, et al.
Publicado: (2011)

Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer’s disease and the potential role of local estrogens
por: Hu, Yu-Ting, et al.
Publicado: (2023)

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease
por: Kaneko, Ryusei, et al.
Publicado: (2023)

Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce ß-Amyloid in Alzheimer’s Disease
por: Dewji, Nazneen N., et al.
Publicado: (2015)

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease
por: González-Marrero, Ibrahim, et al.
Publicado: (2015)

A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer’s disease
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2017)

Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease
por: Okamoto, Masahiro, et al.
Publicado: (2018)

Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein
por: Cho, Yoon Young, et al.
Publicado: (2019)

Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer’s Disease in Amyloid Precursor Protein/Presenilin 1 Mice
por: Zeng, Qing, et al.
Publicado: (2021)

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease
por: Kukreja, Lokesh, et al.
Publicado: (2014)

Erratum: Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens
Publicado: (2023)

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production
por: Green, Kim N., et al.
Publicado: (2008)

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease
por: Honarnejad, Kamran, et al.
Publicado: (2013)

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory
por: Bonds, Jacqueline A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_31gklbsn50gn329ni6s0mr61s9