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Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins
A hallmark of many neurodegenerative diseases is accumulation of misfolded proteins within neurons, leading to cellular dysfunction and cell death. Although several mechanisms have been proposed to link protein misfolding to cellular toxicity, the connection remains enigmatic. Here, we report a cell...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018711/ https://www.ncbi.nlm.nih.gov/pubmed/21079601 http://dx.doi.org/10.1038/nchembio.467 |