Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease

We identified three S. cerevisiae lipid elongase null mutants (elo1Δ, elo2Δ, and elo3Δ) that enhance the toxicity of alpha-synuclein (α-syn). These elongases function in the endoplasmic reticulum (ER) to catalyze the elongation of medium chain fatty acids to very long chain fatty acids, which is a c...

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Detalles Bibliográficos
Autores principales: Lee, Yong Joo, Wang, Shaoxiao, Slone, Sunny R., Yacoubian, Talene A., Witt, Stephan N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019226/
https://www.ncbi.nlm.nih.gov/pubmed/21264320
http://dx.doi.org/10.1371/journal.pone.0015946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019226/
https://www.ncbi.nlm.nih.gov/pubmed/21264320
http://dx.doi.org/10.1371/journal.pone.0015946

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