Cargando…

Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease

We identified three S. cerevisiae lipid elongase null mutants (elo1Δ, elo2Δ, and elo3Δ) that enhance the toxicity of alpha-synuclein (α-syn). These elongases function in the endoplasmic reticulum (ER) to catalyze the elongation of medium chain fatty acids to very long chain fatty acids, which is a c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Yong Joo, Wang, Shaoxiao, Slone, Sunny R., Yacoubian, Talene A., Witt, Stephan N.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019226/ https://www.ncbi.nlm.nih.gov/pubmed/21264320 http://dx.doi.org/10.1371/journal.pone.0015946

Ejemplares similares

14-3-3theta Protects against Neurotoxicity in a Cellular Parkinson's Disease Model through Inhibition of the Apoptotic Factor Bax
por: Slone, Sunny R., et al.
Publicado: (2011)

14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
por: Underwood, Rachel, et al.
Publicado: (2021)

Angiogenin in Parkinson Disease Models: Role of Akt Phosphorylation and Evaluation of AAV-Mediated Angiogenin Expression in MPTP Treated Mice
por: Steidinger, Trent U., et al.
Publicado: (2013)

Novel suppressors of α-synuclein toxicity identified using yeast
por: Liang, Jun, et al.
Publicado: (2008)

Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse
por: Pattanayak, Rudradip, et al.
Publicado: (2022)

The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling - a possible implication for methamphetamine use?
por: Wang, Shaoxiao, et al.
Publicado: (2014)

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
por: Qiao, Liyan, et al.
Publicado: (2008)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Loss of Functional Alpha-Synuclein: A Toxic Event in Parkinson’s Disease?
por: Kanaan, Nicholas M., et al.
Publicado: (2012)

Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
por: García-Revilla, Juan, et al.
Publicado: (2023)

Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
por: Tenreiro, Sandra, et al.
Publicado: (2014)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Alpha-synuclein spreading in Parkinson’s disease
por: Recasens, Ariadna, et al.
Publicado: (2014)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease
por: Wang, Ting, et al.
Publicado: (2015)

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
por: de Oliveira, Rita Machado, et al.
Publicado: (2017)

Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson’s Disease
por: Wang, Shaoxiao, et al.
Publicado: (2016)

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
por: Gómez-Benito, Mónica, et al.
Publicado: (2020)

Alpha-Synuclein and Cognitive Decline in Parkinson Disease
por: Fan, Tian-Sin, et al.
Publicado: (2021)

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
por: de Oliveira, Rita Machado, et al.
Publicado: (2017)

Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
por: Sampaio-Marques, Belém, et al.
Publicado: (2018)

Cerium Oxide Nanoparticles Rescue α-Synuclein-Induced Toxicity in a Yeast Model of Parkinson’s Disease
por: Ruotolo, Roberta, et al.
Publicado: (2020)

Sumoylation Protects Against β-Synuclein Toxicity in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2018)

Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease
por: Maraganore, Demetrius M.
Publicado: (2011)

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
por: Xu, Shengli, et al.
Publicado: (2015)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
por: Zhang, Guoxin, et al.
Publicado: (2018)

The Identification of Alpha-Synuclein as the First Parkinson Disease Gene
por: Nussbaum, Robert L.
Publicado: (2017)

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
por: Fitzgerald, Emily, et al.
Publicado: (2019)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
por: Fields, Carroll Rutherford, et al.
Publicado: (2019)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
por: Li, Puyu, et al.
Publicado: (2021)

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease
por: Oueslati, Abid, et al.
Publicado: (2015)

14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity
por: Pattanayak, Rudradip, et al.
Publicado: (2023)

Temperature-Dependent Structural Changes of Parkinson's Alpha-Synuclein Reveal the Role of Pre-Existing Oligomers in Alpha-Synuclein Fibrillization
por: Ariesandi, Winny, et al.
Publicado: (2013)

Defects in Very Long-Chain Fatty Acid Oxidation Presenting as Different Types of Cardiomyopathy
por: Alaei, Fariba, et al.
Publicado: (2022)

Olfactory Deficits in an Alpha-Synuclein Fly Model of Parkinson’s Disease
por: Chen, Alex Y., et al.
Publicado: (2014)

Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease
por: Cersosimo, Maria Graciela
Publicado: (2015)

Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s Disease
por: Vivacqua, Giorgio, et al.
Publicado: (2016)

Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease
por: Parnetti, Lucilla, et al.
Publicado: (2014)

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
por: Ferreira, Sara A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rkeo0732jd1l8f9oe1n0st1bg9