Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Objectives To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically indicated for amniocentesis or chorionic villus sampling. Design Diagnostic accuracy validated against ful...

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Detalles Bibliográficos
Autores principales: Chiu, Rossa W K, Akolekar, Ranjit, Zheng, Yama W L, Leung, Tak Y, Sun, Hao, Chan, K C Allen, Lun, Fiona M F, Go, Attie T J I, Lau, Elizabeth T, To, William W K, Leung, Wing C, Tang, Rebecca Y K, Au-Yeung, Sidney K C, Lam, Helena, Kung, Yu Y, Zhang, Xiuqing, van Vugt, John M G, Minekawa, Ryoko, Tang, Mary H Y, Wang, Jun, Oudejans, Cees B M, Lau, Tze K, Nicolaides, Kypros H, Lo, Y M Dennis
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019239/
https://www.ncbi.nlm.nih.gov/pubmed/21224326
http://dx.doi.org/10.1136/bmj.c7401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019239/
https://www.ncbi.nlm.nih.gov/pubmed/21224326
http://dx.doi.org/10.1136/bmj.c7401

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