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Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression
The hypoxia inducible factor 1α (HIF-1α) is overexpressed in solid tumors, driving tumor angiogenesis and survival. However, the mechanisms regulating HIF-1α expression in solid tumors are not fully understood. In this study, we find that microtubule integrity and dynamics are intricately involved i...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019555/ https://www.ncbi.nlm.nih.gov/pubmed/21220510 http://dx.doi.org/10.1083/jcb.201004145 |