All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein

BACKGROUND: Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. Unfortunately, most patients responding to imatinib will eventually exhibit imatinib-resistance, the cause of...

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Detalles Bibliográficos
Autores principales: Chi, Hoang Thanh, Ly, Bui Thi Kim, Taguchi, Takahiro, Watanabe, Toshiki, Sato, Yuko
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020167/
https://www.ncbi.nlm.nih.gov/pubmed/21159206
http://dx.doi.org/10.1186/1756-9966-29-165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020167/
https://www.ncbi.nlm.nih.gov/pubmed/21159206
http://dx.doi.org/10.1186/1756-9966-29-165

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