Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells

Introduction: Cyclin D1 (D1) binds to cyclin-dependent kinases (CDK) 4 or 6 to form a holoenzyme that phosphorylates the Rb protein to promote cell cycle progression from G1 to S phase. Therefore, targeting CDK4/6 may be a good strategy for chemotherapy of cancer. We performed a proof-of-principle s...

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Detalles Bibliográficos
Autores principales: Sun, Yuan, Li, Ying-xia, Wu, Hai-jun, Wu, Si-hung, Wang, Y. Alan, Luo, Dian-zhong, Liao, D. Joshua
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020360/
https://www.ncbi.nlm.nih.gov/pubmed/21234300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020360/
https://www.ncbi.nlm.nih.gov/pubmed/21234300

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