Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping

Essential telomere ‘capping' proteins act as a safeguard against ageing and cancer by inhibiting the DNA damage response (DDR) and regulating telomerase recruitment, thus distinguishing telomeres from double-strand breaks (DSBs). Uncapped telomeres and unrepaired DSBs can both stimulate a poten...

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Detalles Bibliográficos
Autores principales: Dewar, James M, Lydall, David
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020640/
https://www.ncbi.nlm.nih.gov/pubmed/21045806
http://dx.doi.org/10.1038/emboj.2010.267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020640/
https://www.ncbi.nlm.nih.gov/pubmed/21045806
http://dx.doi.org/10.1038/emboj.2010.267

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