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Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping
Essential telomere ‘capping' proteins act as a safeguard against ageing and cancer by inhibiting the DNA damage response (DDR) and regulating telomerase recruitment, thus distinguishing telomeres from double-strand breaks (DSBs). Uncapped telomeres and unrepaired DSBs can both stimulate a poten...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020640/ https://www.ncbi.nlm.nih.gov/pubmed/21045806 http://dx.doi.org/10.1038/emboj.2010.267 |